Inhibition of severe acute respiratory syndrome-associated coronavirus infection by equine neutralizing antibody in golden Syrian hamsters.
Identifieur interne : 003673 ( Main/Exploration ); précédent : 003672; suivant : 003674Inhibition of severe acute respiratory syndrome-associated coronavirus infection by equine neutralizing antibody in golden Syrian hamsters.
Auteurs : Guangyu Zhao [République populaire de Chine] ; Bing Ni ; Haiyan Jiang ; Deyan Luo ; Marek Pacal ; Lili Zhou ; Liangyan Zhang ; Li Xing ; Liangyan Zhang ; Zhengcai Jia ; Zhihua Lin ; Li Wang ; Jintao Li ; Yunfei Liang ; Xinfu Shi ; Tingting Zhao ; Liyun Zhou ; Yuzhang Wu ; Xiliang WangSource :
- Viral immunology [ 0882-8245 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antibodies, Viral, Immunoglobulin Fab Fragments.
- prevention & control : Severe Acute Respiratory Syndrome.
- Administration, Intranasal, Animals, Cricetinae, Horses, Mesocricetus, Neutralization Tests, Polymerase Chain Reaction.
Abstract
Equine anti-severe acute respiratory syndrome-associated coronavirus F(ab')(2) has been verified to protect mice from infection with severe acute respiratory syndrome-associated coronavirus (SARS-CoV). However, before potential clinical application, the antibody needs to be tested in as many animal models as possible to ensure its safety and efficiency. In this study, after verification by various methods that the golden Syrian hamster constitutes a model susceptible to SARS-CoV infection, we confirmed that the antibody could protect animals completely from SARS-CoV infection in the preventive setting. More importantly, the antibody could reduce viral titers or copies by approximately 10(3)- to 10(4)-fold in animal lung after virus exposure, compared with negative control. These data provide further evidence to warrant clinical studies of this antibody in the treatment and prevention of SARS.
DOI: 10.1089/vim.2006.0064
PubMed: 17425434
Affiliations:
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type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Ni, Bing" sort="Ni, Bing" uniqKey="Ni B" first="Bing" last="Ni">Bing Ni</name></author><author><name sortKey="Jiang, Haiyan" sort="Jiang, Haiyan" uniqKey="Jiang H" first="Haiyan" last="Jiang">Haiyan Jiang</name></author><author><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name></author><author><name sortKey="Pacal, Marek" sort="Pacal, Marek" uniqKey="Pacal M" first="Marek" last="Pacal">Marek Pacal</name></author><author><name sortKey="Zhou, Lili" sort="Zhou, Lili" uniqKey="Zhou L" first="Lili" last="Zhou">Lili Zhou</name></author><author><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name></author><author><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name></author><author><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name></author><author><name sortKey="Jia, Zhengcai" sort="Jia, Zhengcai" uniqKey="Jia Z" first="Zhengcai" last="Jia">Zhengcai Jia</name></author><author><name sortKey="Lin, Zhihua" sort="Lin, Zhihua" uniqKey="Lin Z" first="Zhihua" last="Lin">Zhihua Lin</name></author><author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name></author><author><name sortKey="Li, Jintao" sort="Li, Jintao" uniqKey="Li J" first="Jintao" last="Li">Jintao Li</name></author><author><name sortKey="Liang, Yunfei" sort="Liang, Yunfei" uniqKey="Liang Y" first="Yunfei" last="Liang">Yunfei Liang</name></author><author><name sortKey="Shi, Xinfu" sort="Shi, Xinfu" uniqKey="Shi X" first="Xinfu" last="Shi">Xinfu Shi</name></author><author><name sortKey="Zhao, Tingting" sort="Zhao, Tingting" uniqKey="Zhao T" first="Tingting" last="Zhao">Tingting Zhao</name></author><author><name sortKey="Zhou, Liyun" sort="Zhou, Liyun" uniqKey="Zhou L" first="Liyun" last="Zhou">Liyun Zhou</name></author><author><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name></author><author><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name></author></analytic><series><title level="j">Viral immunology</title><idno type="ISSN">0882-8245</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Antibodies, Viral (immunology)</term><term>Cricetinae</term><term>Horses</term><term>Immunoglobulin Fab Fragments (immunology)</term><term>Mesocricetus</term><term>Neutralization Tests</term><term>Polymerase Chain Reaction</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Cricetinae</term><term>Equus caballus</term><term>Fragments Fab d'immunoglobuline (immunologie)</term><term>Mesocricetus</term><term>Réaction de polymérisation en chaîne</term><term>Syndrome respiratoire aigu sévère ()</term><term>Tests de neutralisation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin Fab Fragments</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Fragments Fab d'immunoglobuline</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Intranasal</term><term>Animals</term><term>Cricetinae</term><term>Horses</term><term>Mesocricetus</term><term>Neutralization Tests</term><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie nasale</term><term>Animaux</term><term>Cricetinae</term><term>Equus caballus</term><term>Mesocricetus</term><term>Réaction de polymérisation en chaîne</term><term>Syndrome respiratoire aigu sévère</term><term>Tests de neutralisation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Equine anti-severe acute respiratory syndrome-associated coronavirus F(ab')(2) has been verified to protect mice from infection with severe acute respiratory syndrome-associated coronavirus (SARS-CoV). However, before potential clinical application, the antibody needs to be tested in as many animal models as possible to ensure its safety and efficiency. In this study, after verification by various methods that the golden Syrian hamster constitutes a model susceptible to SARS-CoV infection, we confirmed that the antibody could protect animals completely from SARS-CoV infection in the preventive setting. More importantly, the antibody could reduce viral titers or copies by approximately 10(3)- to 10(4)-fold in animal lung after virus exposure, compared with negative control. These data provide further evidence to warrant clinical studies of this antibody in the treatment and prevention of SARS.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><noCountry><name sortKey="Jia, Zhengcai" sort="Jia, Zhengcai" uniqKey="Jia Z" first="Zhengcai" last="Jia">Zhengcai Jia</name><name sortKey="Jiang, Haiyan" sort="Jiang, Haiyan" uniqKey="Jiang H" first="Haiyan" last="Jiang">Haiyan Jiang</name><name sortKey="Li, Jintao" sort="Li, Jintao" uniqKey="Li J" first="Jintao" last="Li">Jintao Li</name><name sortKey="Liang, Yunfei" sort="Liang, Yunfei" uniqKey="Liang Y" first="Yunfei" last="Liang">Yunfei Liang</name><name sortKey="Lin, Zhihua" sort="Lin, Zhihua" uniqKey="Lin Z" first="Zhihua" last="Lin">Zhihua Lin</name><name sortKey="Luo, Deyan" sort="Luo, Deyan" uniqKey="Luo D" first="Deyan" last="Luo">Deyan Luo</name><name sortKey="Ni, Bing" sort="Ni, Bing" uniqKey="Ni B" first="Bing" last="Ni">Bing Ni</name><name sortKey="Pacal, Marek" sort="Pacal, Marek" uniqKey="Pacal M" first="Marek" last="Pacal">Marek Pacal</name><name sortKey="Shi, Xinfu" sort="Shi, Xinfu" uniqKey="Shi X" first="Xinfu" last="Shi">Xinfu Shi</name><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name><name sortKey="Wang, Xiliang" sort="Wang, Xiliang" uniqKey="Wang X" first="Xiliang" last="Wang">Xiliang Wang</name><name sortKey="Wu, Yuzhang" sort="Wu, Yuzhang" uniqKey="Wu Y" first="Yuzhang" last="Wu">Yuzhang Wu</name><name sortKey="Xing, Li" sort="Xing, Li" uniqKey="Xing L" first="Li" last="Xing">Li Xing</name><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><name sortKey="Zhang, Liangyan" sort="Zhang, Liangyan" uniqKey="Zhang L" first="Liangyan" last="Zhang">Liangyan Zhang</name><name sortKey="Zhao, Tingting" sort="Zhao, Tingting" uniqKey="Zhao T" first="Tingting" last="Zhao">Tingting Zhao</name><name sortKey="Zhou, Lili" sort="Zhou, Lili" uniqKey="Zhou L" first="Lili" last="Zhou">Lili Zhou</name><name sortKey="Zhou, Liyun" sort="Zhou, Liyun" uniqKey="Zhou L" first="Liyun" last="Zhou">Liyun Zhou</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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